eSupervisor Detail

About me

*Professional Summary* API R&D leader with 19.5 years of experience in pharmaceutical process research and development, specializing in organometallic catalysis and green chemistry. Proven track record of designing and commercializing scalable, cost-effective synthetic routes using Pd, Ru, Rh, and Ni-catalyzed transformations including Suzuki, Buchwald-Hartwig, Heck, and C-H activation. Expert in route scouting, catalyst/ligand screening, and process optimization from lab to multi-kg scale

Interests: *Research Interests* My research interests lie at the intersection of organometallic chemistry, homogeneous catalysis, and sustainable pharmaceutical synthesis. With 19.5 years of industrial API R&D experience, I am particularly interested in: 1. *Base-metal catalysis*: Developing Ni, Co, Fe, and Mn complexes to replace Pd/Ru in cross-coupling, C-H activation, and hydrogenation reactions for cost-effective and sustainable API manufacturing. 2. *Ligand design for selectivity*: Engineering phosphine, NHC, and pincer ligands to control chemo-, regio-, and enantioselectivity in complex molecule synthesis, with focus on reducing catalyst loading and improving TON/TON. 3. *Mechanistic studies & reaction engineering*: Using in situ NMR, IR, and kinetic profiling to elucidate catalytic cycles and deactivation pathways, enabling rational catalyst improvement under process-relevant conditions. 4. *Green catalytic transformations*: CO2 utilization, photoredox catalysis, and electrochemical methods to enable atom-economical C-C and C-N bond formation with minimal waste. 5. *Catalysis translation*: Bridging academic catalyst discovery with industrial application, focusing on robustness, metal leaching, and compatibility with flow chemistry and GMP requirements. Long-term goal: Design next-generation organometallic catalysts that are not only academically novel but also industrially viable for affordable,