
Research Scientist
Rajni Shaw
Experiment Design
About me
I completed my PhD in Cancer Biology from IICB, Kolkata, in December 2024. I have a strong background in molecular & cell biology and animal modelling (rat and mouse). By integrating my expertise, I aim to mentor senior students in developing hypotheses, help them interpret data to scientifically sound conclusions, lead them in the responsible and methodical handling of in vivo models, motivate them to think critically, and encourage them to think outside the box when results are unexpected.
Interests: My research interests focus on the intersection of molecular oncology and translational medicine. I am driven by a central question: How can we decode the complex molecular signatures of individual cancer cells to design more effective, patient-specific treatments? By combining high-throughput bioinformatics with rigorous wet-lab validation, I aim to identify novel therapeutic targets that bypass drug resistance and improve patient outcomes. A core component of my research involves bridging the gap between in vitro discovery and in vivo application. I utilize cancer cell line models and animal modelling (mouse/rat) to test the efficacy of targeted therapies in a physiological context. My focus is on: Functional Assays: Quantifying the impact of novel compounds on metastasis and cell viability through wound-healing, colony formation, and MTT assays. Biomarker Discovery: Leveraging DNA/RNA isolation and transcriptomic data to identify molecular "red flags" that predict how a specific tumor will respond to treatment. Drug Resistance: Investigating the molecular adaptations that lead to therapy failure, with the goal of developing "combination cocktails" tailored to the genetic profile of the individual patient.
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