Manisha Yadav

Research Associate

Experiment Design

Karnataka, India

2 Years

Joined Mar 2026

Indian Institute Of Science

Department Of Developmental Biology And Genetics

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About me

Postdoctoral Researcher at IISc Bangalore studying intestinal inflammation in IBD and Crohn’s disease using Citrobacter-infected murine models. Previously worked at Albert Einstein College of Medicine on glycosylation in melanoma metastasis and prostate cancer. Ph.D. from CSIR-IMTECH on TGF-β/c-Src/CLEC-2 regulation of dendritic cell migration during Leishmania donovani infection. Expertise includes immunology, host–pathogen interactions, molecular signaling, and murine disease models.

Interests: My research interest centers on understanding immune signaling mechanisms that regulate host–pathogen interactions and inflammatory diseases, particularly within the intestinal mucosa. I aim to dissect how innate and adaptive immune pathways control epithelial barrier integrity, dendritic cell function, and cytokine-driven responses during infection and chronic inflammation. I am also interested in transcriptional and post-translational regulation of immune receptors. My long-term goal is to identify molecular targets that modulate immune dysregulation and develop therapeutic strategies for inflammatory, infectious, and immune-mediated diseases.

Skills

I hold expertise in the Mammalian cell culture, Animal handling, Primary cells isolation, Mammalian cell culture, Small Intestine and Colonic Organoid culture, Flow cytometry, Co-immunoprecipitation (Co-IP), Western blotting, RT-PCR, Electrophoretic mobility shift assay (EMSA), Chromatin immunoprecipitation (ChIP) and Confocal microscopy. I am trained to work in the BSL-2 facility and have handled drug-sensitive and resistant Leishmania strains

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